Article
Genetic polymorphisms in ethanol metabolism: issues and goals for physiologically based pharmacokinetic modeling.
Drug and chemical toxicology - 1 Feb 2000
Pastino G M, Flynn E J, Sultatos L G
Abstract excerpt
Chronic exposure to excessive ethanol consumption has adverse effects on virtually all organs and tissues in the body, including but not limited to the liver, pancreas, reproductive organs, central nervous system, and the fetus. Exposure to ethanol can also enhance the toxicity of other chemicals. Not all persons exposed to the same amount of ethanol experience the same degree of adverse effects. For example,...
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