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Article

Genetic Associations of Alcohol and Aldehyde Dehydrogenase With Alcohol Dependence and Their Mechanisms of Action

1 Dec 2005

Abstract excerpt

Two alcohol dehydrogenase genes (ADHIB and ADH1C on chromosome 4) and one aldehyde dehydrogenase gene (ALDH2 on chromosome 12) exhibit functional polymorphisms that are associated with lower rates of alcohol dependence. The ALDH2*2 allele,found almost exclusively in Asian populations, has the strongest relationship. The ADH1B*2, ADH1B*3, and ADHlC*i alleles, found in varying prevalence in different ethnic groups,...

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PMID: 16404797
DOI: 10.1097/01.ftd.0000179840.78762.33

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