Article
Association of the ADH2*3 allele with a negative family history of alcoholism in African American young adults.
Alcoholism, clinical and experimental research - 1 Dec 2001
Ehlers C L, Gilder D A, Harris L, Carr L
Abstract excerpt
BACKGROUND: Two of the class I alcohol dehydrogenase (ADH) genes (ADH2 and ADH3) encode for multiple isozymes that differ in their kinetic properties. Polymorphisms at both of these gene loci have been linked to alcoholism and/or alcohol-induced disabilities in some populations. At the ADH2 locus, three polymorphisms are present (ADH2*1, ADH2*2, ADH2*3). ADH2*3 allele codes for a high Km and Vmax variant that has...
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