Article
Health-related effects of genetic variations of alcohol-metabolizing enzymes in African Americans.
Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism - 1 Jan 2007
Scott Denise M, Taylor Robert E
Abstract excerpt
Alcohol metabolism involves two key enzymes-alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). There are several types of ADH and ALDH, each of which may exist in several variants (i.e., isoforms) that differ in their ability to break down alcohol and its toxic metabolite acetaldehyde. The isoforms are encoded by different gene variants (i.e., alleles) whose distribution among ethnic groups differs....
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