Article
Immunohistochemical detection of p53 in melanomas with rare p53 gene mutations is associated with mdm-2 overexpression.
Oncology research - 1 Jan 1995
Poremba C, Yandell D W, Metze D, Kamanabrou D, Böcker W, Dockhorn-Dworniczak B
Abstract excerpt
Expression of mutant p53 detected by immunohistochemistry has been described in human malignant melanoma, but there are few reports of molecular analyses. To investigate the genetic basis for p53 expression in malignant melanoma, we examined 58 primary tumors and 5 cutaneous metastases. The entir...
Topics
- Base Sequence
- Genes, p53
- Humans
- Immunohistochemistry
- Melanoma
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-mdm2
- Skin Neoplasms
- Tumor Suppressor Protein p53