Article
Immunohistochemical detection of p53 in melanomas with rare p53 gene mutations is associated with mdm-2 overexpression.
Oncology research - 1 Jan 1995
Poremba C, Yandell D W, Metze D, Kamanabrou D, Böcker W, Dockhorn-Dworniczak B
Abstract excerpt
Expression of mutant p53 detected by immunohistochemistry has been described in human malignant melanoma, but there are few reports of molecular analyses. To investigate the genetic basis for p53 expression in malignant melanoma, we examined 58 primary tumors and 5 cutaneous metastases. The entire coding sequence of the p53 gene was screened by single-strand conformation polymorphism analysis and direct genomic...
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