Article
p53 gene mutation and expression in naevi and melanomas.
Melanoma research - 1 Apr 1995
Sparrow L E, Soong R, Dawkins H J, Iacopetta B J, Heenan P J
Abstract excerpt
Mutations of the p53 tumour suppressor gene are common to many human malignancies. Although increased p53 expression has been observed in cutaneous malignant melanoma, mutations of the p53 gene appear to be infrequent. We examined 140 benign and malignant paraffin-embedded melanocytic lesions for p53 protein expression by immunohistochemistry, using the monoclonal anti-p53 antibody DO-7 and a microwave method of...
Topics
- Base Sequence
- DNA, Neoplasm
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans
- Immunohistochemistry
- Melanoma
- Molecular Sequence Data
- Mutation
- Nevus
- Polymerase Chain Reaction