Overexpression and mutations of p53 in metastatic malignant melanomas.

doi:10.1002/(SICI)1097-0215(19960729)67:3<313::AID-IJC1>3.0.CO;2-U

Back to search

Article

Overexpression and mutations of p53 in metastatic malignant melanomas.

International journal of cancer - 29 Jul 1996

Hartmann A, Blaszyk H, Cunningham J S, McGovern R M, Schroeder J S, Helander S D, Pittelkow M R, Sommer S S, Kovach J S

Abstract excerpt

Alterations of the p53 tumor suppressor gene are the most frequent genetic abnormalities in human malignancies, but the role of p53 in the etiology of malignant melanomas is unclear. Fifty unselected malignant melanomas were analyzed for p53 overexpression by immunohistochemistry using 3 monoclon...

Topics

Genes, p53
Humans
Immunohistochemistry
Melanoma
Mutation
Polymorphism, Genetic
Tumor Suppressor Protein p53

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.