Article
Prognostic implications of p53 overexpression in cutaneous melanoma from sun-exposed and nonexposed sites.
Cancer - 15 Jan 1998
Essner R, Kuo C T, Wang H, Wen D R, Turner R R, Nguyen T, Hoon D S
Abstract excerpt
BACKGROUND: There is increasing evidence that mutations in the p53 tumor suppressor gene are among the most common genetic alterations in human malignancies. Because ultraviolet light can induce specific p53 mutations and is linked to the development of skin cancers, this study was done to determ...
Topics
- Adult
- Age Factors
- Animals
- Antibodies, Monoclonal
- Biopsy
- Chi-Square Distribution
- Coloring Agents
- Environmental Exposure
- Extremities
- Female
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Head and Neck Neoplasms
- Humans
- Lymphatic Metastasis
- Male
- Melanoma
- Mice