Article
The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship?
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2000
Hussein Mahmoud R
Abstract excerpt
Mutations in the TP53 gene are found in about 11% of melanomas. Although nearly 600 papers have been published with varying degrees of consensus, there does not appear to be any comparable analysis that facilitates more than a glimpse into the role of p53 in melanomagenesis. This article reviews p53 alterations (at the gene and protein levels) in melanocytic skin lesions and discusses the following points: (i)...
Topics
- Codon
- Genes, p53
- Humans
- Melanocytes
- Melanoma
- Mutation
- Skin Diseases
- Skin Neoplasms