Article
The role of TP53 and MDM2 polymorphisms in TP53 mutagenesis and risk of non-melanoma skin cancer.
Carcinogenesis - 1 Mar 2011
Almquist Lindsay M, Karagas Margaret R, Christensen Brock C, Welsh Marleen M, Perry Ann E, Storm Craig A, Nelson Heather H
Abstract excerpt
P53 is a key regulatory molecule in the cellular response to ultraviolet radiation, and TP53 mutation is the most common alteration in non-melanoma skin cancer. The MDM2 oncogene negatively regulates p53 protein levels, and both genes have functional polymorphisms that may modify skin cancer risk. Furthermore, prior research suggests that TP53 mutations preferentially occur on the arginine allele to selectively...
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