TP53 allele loss, mutations and expression in malignant melanoma.

doi:10.1038/bjc.1994.48

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Article

TP53 allele loss, mutations and expression in malignant melanoma.

British journal of cancer - 1 Feb 1994

Flørenes V A, Oyjord T, Holm R, Skrede M, Børresen A L, Nesland J M, Fodstad O

Abstract excerpt

p53 alterations at the DNA, mRNA and protein levels were studied in tumour metastases sampled from 30 patients with malignant melanoma. Paraffin-embedded sections from these and an additional 12 patients were examined for the presence of p53 protein. TP53 gene aberrations were found in 7 of 30 (2...

Topics

Alleles
Chromosome Deletion
Genes, p53
Humans
Melanoma
Neoplasm Proteins
Point Mutation
Polymorphism, Restriction Fragment Length
RNA, Messenger
Tumor Suppressor Protein p53

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