Article
Dopamine D4 receptor variant in Africans, D4valine194glycine, is insensitive to dopamine and clozapine: report of a homozygous individual.
American journal of medical genetics - 22 Jan 1996
Liu I S, Seeman P, Sanyal S, Ulpian C, Rodgers-Johnson P E, Serjeant G R, Van Tol H H
Abstract excerpt
The D4Valine194Glycine receptor is a variant of the dopamine D4 receptor and is found in 12.5% of the Afro-Caribbean population. Glycine replaces valine at a position one amino acid away from a serine which is critical for the attachment of dopamine. To determine whether this mutation had an effect on the properties of the dopamine D4 receptor, we constructed this variant and tested the sensitivity of the...
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