Article
Dopamine D4 receptor variant in Africans, D4valine194glycine, is insensitive to dopamine and clozapine: report of a homozygous individual.
American journal of medical genetics - 22 Jan 1996
Liu I S, Seeman P, Sanyal S, Ulpian C, Rodgers-Johnson P E, Serjeant G R, Van Tol H H
Abstract excerpt
The D4Valine194Glycine receptor is a variant of the dopamine D4 receptor and is found in 12.5% of the Afro-Caribbean population. Glycine replaces valine at a position one amino acid away from a serine which is critical for the attachment of dopamine. To determine whether this mutation had an effe...
Topics
- Adolescent
- Black or African American
- Base Sequence
- Binding, Competitive
- Clozapine
- Cyclic AMP
- Dopamine
- Genetic Variation
- Humans
- Male
- Molecular Sequence Data
- Receptors, Dopamine D2
- Receptors, Dopamine D4
- Spiperone
- West Indies