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Article

Human genetic variations in the 5HT2A receptor: a single nucleotide polymorphism identified with altered response to clozapine.

Pharmacogenetics - 1 Feb 2003

Harvey Layne, Reid Ronald E, Ma Caixia, Knight Peter J K, Pfeifer Tom A, Grigliatti Thomas A

Abstract excerpt

OBJECTIVE: to determine if the agonist serotonin and antagonists loxapine and clozapine have an altered potency for four allelic variants (T25N, I197V, A447V, and H452Y) of the human 5HT2A receptor when compared to the wild-type allele. METHODS: The receptor or its variants are studied in an in-vitro functional assay system consisting of a Sf9 insect cell line that is stably transformed with the human wild-type...

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Identifiers

PMID: 12563180
DOI: 10.1097/00008571-200302000-00007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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