Dopamine D4 receptor variant, D4GLYCINE194, in Africans, but not in Caucasians: no association with schizophrenia.

doi:10.1002/ajmg.1320540419

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Article

Dopamine D4 receptor variant, D4GLYCINE194, in Africans, but not in Caucasians: no association with schizophrenia.

American journal of medical genetics - 15 Dec 1994

Seeman P, Ulpian C, Chouinard G, Van Tol H H, Dwosh H, Lieberman J A, Siminovitch K, Liu I S, Waye J, Voruganti P

Abstract excerpt

Because antipsychotic drugs selectively block dopamine receptors and since dopamine D4 receptors are elevated sixfold in postmortem schizophrenia brain, we searched for possible abnormalities in the coding region of the genomic DNA sequence for the dopamine D4 receptor in control and schizophrenia tissues. The DNA sequence for the first 250 bases of exon 3 of this receptor was examined in the genomic DNA from 296...

Topics

Adult
Africa
Amino Acid Sequence
Base Sequence
Black People
Brain
DNA
Exons
Female
Genetic Variation
Glycine
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Molecular Sequence Data

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Prevalence

Source

Open in PubMed

Identifiers

PMID: 7726213
DOI: 10.1002/ajmg.1320540419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7726213-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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