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Article

Identification of single nucleotide polymorphisms of the human metabotropic glutamate receptor 1 gene and pharmacological characterization of a P993S variant.

Biochemical pharmacology - 1 Apr 2009

Downey Patrick M, Petrò Roberta, Simon Jason S, Devlin David, Lozza Gianluca, Veltri Alessio, Beltramo Massimiliano, Bertorelli Rosalia, Reggiani Angelo

Abstract excerpt

mGluR1 receptors are believed to play major roles in the pathophysiology of diseases such as anxiety and chronic pain and are being actively investigated as targets for drug development. Sequence polymorphisms can potentially influence the efficacy of drugs in patient populations and are therefore an important consideration in the drug development process. To identify DNA sequence variants of the mGluR1 receptor,...

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Source

Identifiers

PMID: 19146831
DOI: 10.1016/j.bcp.2008.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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