Article
Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome.
Development (Cambridge, England) - 1 Oct 1995
Patapoutian A, Yoon J K, Miner J H, Wang S, Stark K, Wold B
Abstract excerpt
MRF4 (herculin/Myf-6) is one of the four member MyoD family of transcription factors identified by their ability to enforce skeletal muscle differentiation upon a wide variety of nonmuscle cell types. In this study the mouse germline MRF4 gene was disrupted by targeted recombination. Animals homo...
Topics
- Animals
- Base Sequence
- DNA Primers
- Female
- Gene Expression Regulation, Developmental
- Gene Targeting
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Morphogenesis
- Muscle, Skeletal
- Myogenic Regulatory Factors
- Myogenin
- Phenotype
- Polymerase Chain Reaction
- Ribs
- Transcription Factors