Article
Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome.
Development (Cambridge, England) - 1 Oct 1995
Patapoutian A, Yoon J K, Miner J H, Wang S, Stark K, Wold B
Abstract excerpt
MRF4 (herculin/Myf-6) is one of the four member MyoD family of transcription factors identified by their ability to enforce skeletal muscle differentiation upon a wide variety of nonmuscle cell types. In this study the mouse germline MRF4 gene was disrupted by targeted recombination. Animals homozygous for the MRF4bh1 allele, a deletion of the functionally essential bHLH domain, displayed defective axial...
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