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Article

Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently.

Development (Cambridge, England) - 1 Jul 1997

Wang Y, Jaenisch R

Abstract excerpt

The myogenic basic Helix-Loop-Helix transcription factors, including Myf5, MyoD, myogenin (myg) and MRF4, play important roles in skeletal muscle development. The phenotypes of mutant mice deficient in either gene are different, suggesting that each gene may have a unique function in vivo. We previously showed that targeting myogenin into the Myf5 locus (Myf5(myg-ki)) rescued the rib cage truncation in the...

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Identifiers

PMID: 9216993
DOI: 10.1242/dev.124.13.2507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently.PMID 9216993Read ↗

Targeted inactivation of myogenic factor genes reveals their role during mouse myogenesis: a review.Semantic proximity Read ↗

Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis.Semantic proximity Read ↗

Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice.Semantic proximity Read ↗

Myf-5 revisited: loss of early myotome formation does not lead to a rib phenotype in homozygous Myf-5 mutant mice.Semantic proximity Read ↗

MRF4 can substitute for myogenin during early stages of myogenesis.Semantic proximity Read ↗

Myogenin Regulates Exercise Capacity but Is Dispensable for Skeletal Muscle Regeneration in Adult mdx MiceSemantic proximity Read ↗

Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene.Semantic proximity Read ↗

Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis.Semantic proximity Read ↗

Myf-5 and myoD genes are activated in distinct mesenchymal stem cells and determine different skeletal muscle cell lineages.Semantic proximity Read ↗

MyoD or Myf-5 is required for the formation of skeletal muscle.Semantic proximity Read ↗

Myogenin is required for late but not early aspects of myogenesis during mouse development.Semantic proximity Read ↗

ES-cells carrying two inactivated myf-5 alleles form skeletal muscle cells: activation of an alternative myf-5-independent differentiation pathway.Semantic proximity Read ↗

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