Article
Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice.
Nature - 23 Sept 2004
Kassar-Duchossoy Lina, Gayraud-Morel Barbara, Gomès Danielle, Rocancourt Didier, Buckingham Margaret, Shinin Vasily, Tajbakhsh Shahragim
Abstract excerpt
In vertebrates, skeletal muscle is a model for the acquisition of cell fate from stem cells. Two determination factors of the basic helix-loop-helix myogenic regulatory factor (MRF) family, Myf5 and Myod, are thought to direct this transition because double-mutant mice totally lack skeletal muscle fibres and myoblasts. In the absence of these factors, progenitor cells remain multipotent and can change their fate....
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