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Article

Loss of heterozygosity in the VNTR region of intron 1 of P53 in two retinoblastoma cases.

Pediatric hematology and oncology - 1 Jan 2000

Emre S, Sungur A, Bilgiç S, Büyükpamukçu M, Günalp I, Ozgüç M

Abstract excerpt

Loss of heterozygosity (LOH) was studied in 10 primary retinoblastoma tumors in the VNTR region of intron 1 in p53 gene by the polymerase chain reaction. To our knowledge mutations have not been reported in the p53 gene in retinoblastoma primary tumors. Heterozygosity was found at this region in 5 of 10 cases. Two pathology paraffin block samples showed loss of heterozygosity.

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Identifiers

PMID: 8735341
DOI: 10.3109/08880019609030824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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