Article
Human pituitary adenomas show no loss of heterozygosity at the retinoblastoma gene locus.
The Journal of clinical endocrinology and metabolism - 1 Apr 1994
Zhu J, Leon S P, Beggs A H, Busque L, Gilliland D G, Black P M
Abstract excerpt
The retinoblastoma tumor suppressor gene (RB1) is inactivated in hereditary and sporadic forms of retinoblastoma as well as in a number of other sporadic tumors. The majority of human pituitary tumors have been shown to be monoclonal neoplasms, suggesting that 1 or more somatic mutations are invo...
Topics
- Adenoma
- Adolescent
- Adult
- Aged
- Alleles
- Base Sequence
- DNA, Neoplasm
- Female
- Gene Expression Regulation, Neoplastic
- Genes, Retinoblastoma
- Heterozygote
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Pituitary Neoplasms
- Polymerase Chain Reaction
- Polymorphism, Genetic