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Article

Human pituitary adenomas show no loss of heterozygosity at the retinoblastoma gene locus.

The Journal of clinical endocrinology and metabolism - 1 Apr 1994

Zhu J, Leon S P, Beggs A H, Busque L, Gilliland D G, Black P M

Abstract excerpt

The retinoblastoma tumor suppressor gene (RB1) is inactivated in hereditary and sporadic forms of retinoblastoma as well as in a number of other sporadic tumors. The majority of human pituitary tumors have been shown to be monoclonal neoplasms, suggesting that 1 or more somatic mutations are involved in the clonal expansion of a single progenitor cell. Recently, a high percentage of transgenic mice containing a...

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PMID: 8157722
DOI: 10.1210/jcem.78.4.8157722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human pituitary adenomas show no loss of heterozygosity at the retinoblastoma gene locus.PMID 8157722Read ↗

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