Molecular analysis of the retinoblastoma gene in primary ovarian cancer cells.

doi:10.1002/ijc.2910580508

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Article

Molecular analysis of the retinoblastoma gene in primary ovarian cancer cells.

International journal of cancer - 1 Sept 1994

Liu Y, Heyman M, Wang Y, Falkmer U, Hising C, Székely L, Einhorn S

Abstract excerpt

Loss of heterozygosity (LOH) at the site of the retinoblastoma (RB1) gene, at 13q14, has been shown to occur in a high proportion of ovarian cancer patients. Based on this, RB1 gene inactivation was studied in primary tumor cells from 15 patients with ovarian cancer. Structural changes as well as...

Topics

Chromosomes, Human, Pair 13
DNA Primers
Female
Genes, Retinoblastoma
Heterozygote
Humans
Mutation
Ovarian Neoplasms
RNA, Messenger
RNA, Neoplasm
Retinoblastoma Protein
Tumor Cells, Cultured

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