Article
Use of microdissection and molecular genetics in the pathologic diagnosis of retinoblastoma.
Retina (Philadelphia, Pa.) - 1 Jan 1999
Whitcup S M, Park W S, Gasch A T, Eagle R C, Filie A C, Nussenblatt R B, Zhuang Z, Chan C C
Abstract excerpt
BACKGROUND/PURPOSE: Retinoblastoma results from mutations or loss of both alleles of the retinoblastoma gene. Although retinoblastoma is usually recognized clinically, some forms of the disease can elude diagnosis. The purpose of this study was to determine whether the use of molecular genetics to detect a loss of heterozygosity (LOH) in the retinoblastoma gene could assist the ocular pathologist in the diagnosis...
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