Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of heterozygosity and mutations are the major mechanisms of RB1 gene inactivation in Chinese with sporadic retinoblastoma.

Human mutation - 1 Nov 2002

Choy Kwong Wai, Pang Chi Pui, Yu Christopher B O, Wong Hing Lok, Ng Joan S K, Fan Dorothy S P, Lo Kwok Wai, Chai Joshua T Y, Wang Jianhua, Fu Weiling, Lam Dennis S C

Abstract excerpt

We investigated sequence alternation, promoter methylation, and loss of heterozygosity (LOH) of the RB1 gene as possible mechanisms of its inactivation in retinoblastoma. In 42 Chinese patients with sporadic retinoblastoma, the promoter and entire coding region of RB1 were examined for sequence changes. Status of methylation of the CpG-rich island at the 5'end was determined by methylation specific PCR assay. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 13
Share to CpG Islands

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Genes, Retinoblastoma

Share to Loss of Heterozygosity

Share to Retinal Neoplasms

Share to Retinoblastoma

Share to Retinoblastoma Protein

Source

Identifiers

PMID: 12402348
DOI: 10.1002/humu.9077

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of heterozygosity and mutations are the major mechanisms of RB1 gene inactivation in Chinese with sporadic retinoblastoma.PMID 12402348Read ↗

Molecular studies of loss of heterozygosity in Chinese sporadic retinoblastoma patients.Semantic proximity Read ↗

Spectrum of RB1 Germline Mutations and Clinical Features in Unrelated Chinese Patients With RetinoblastomaSemantic proximity Read ↗

Spectrum of RB1 gene mutations and loss of heterozygosity in Mexican patients with retinoblastoma: identification of six novel mutations.Semantic proximity Read ↗

Novel mutations in the RB1 gene from Chinese families with a history of retinoblastoma.Semantic proximity Read ↗

RB1 gene mutations in retinoblastoma.Semantic proximity Read ↗

RB1 Gene Mutations and Genetic Spectrum in Retinoblastoma CasesSemantic proximity Read ↗

Mechanisms of loss of heterozygosity in retinoblastomaSemantic proximity Read ↗

Spectrum of RB1 mutations identified in 403 retinoblastoma patients.Semantic proximity Read ↗

Novel insights into RB1 mutation.Semantic proximity Read ↗

[Characteristics of RB1 gene mutations in Chinese patients with retinoblastoma].Semantic proximity Read ↗

Molecular mechanisms of oncogenic mutations in tumors from patients with bilateral and unilateral retinoblastoma.Semantic proximity Read ↗

Mutational screening of the RB1 gene in Indian patients with retinoblastoma reveals eight novel and several recurrent mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.