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Article

Complete association of loss of heterozygosity of chromosomes 13 and 17 in osteosarcoma.

Cancer genetics and cytogenetics - 1 May 1991

Scheffer H, Kruize Y C, Osinga J, Kuiken G, Oosterhuis J W, Leeuw J A, Schraffordt Koops H, Buys C H

Abstract excerpt

Mutations of the retinoblastoma (RB1) gene are not confined to retinoblastoma, but are also involved in the development of osteosarcoma. Structural aberrations within the RB1 gene have been studied in fresh samples of eleven cases of osteosarcoma. In five cases a rearrangement was detected, one of which was best explained as a partial duplication. The chromosomal mechanisms by which the nonmutated RB1 allele was...

Topics

Adolescent
Adult
Child
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 17
DNA Probes
Female
Genes, Retinoblastoma
Heterozygote
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Nucleic Acid Hybridization

Osteosarcoma

Source

Identifiers

PMID: 2036639
DOI: 10.1016/0165-4608(91)90113-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2036639-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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