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Article

Loss of heterozygosity of the retinoblastoma gene is correlated with the altered pRb expression in human endometrial cancer.

Virchows Archiv : an international journal of pathology - 1 Dec 2002

Semczuk Andrzej, Marzec Barbara, Roessner Albert, Jakowicki Jerzy A, Wojcierowski Jacek, Schneider-Stock Regine

Abstract excerpt

The retinoblastoma (Rb) gene was the first tumor suppressor gene to be discovered; however, data on the influence of Rb inactivation on endometrial carcinogenesis are scarce. We investigated 46 paired primary human endometrial carcinomas and normal tissues to assess the frequency of loss of heterozygosity (LOH) in Rb and 20 tumor pairs to detect the frequency of p53 LOH. Moreover, expression of the retinoblastoma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12461615
DOI: 10.1007/s00428-002-0695-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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