Article
[The status of p53 gene in the primary retinoblastoma].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology - 1 Jul 1999
Huang Q
Abstract excerpt
OBJECTIVE: This study was designed to investigate whether development or progression of retinoblastoma is related with p53 gene mutation. METHODS: A total of 52 cases with primary retinoblastoma were investigated for p53 gene point mutations. To do this, entire coding sequence, including exon 2 - 11, and their vicinity intron sequence were examined by polymerase chain reaction-single strand conformation...
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