Simple and rapid detection of factor V Leiden by allele-specific PCR amplification.

Article

Simple and rapid detection of factor V Leiden by allele-specific PCR amplification.

Thrombosis and haemostasis - 1 May 1996

Blasczyk R, Ritter M, Thiede C, Wehling J, Hintz G, Neubauer A, Riess H

Abstract excerpt

Resistance to activated protein C is the most common hereditary cause for thrombosis and significantly linked to factor V Leiden. In this study, primers were designed to identify the factor V mutation by allele-specific PCR amplification. 126 patients with thromboembolic events were analysed usin...

Topics

Alleles
Base Sequence
Drug Resistance
Factor V
Humans
Molecular Sequence Data
Polymerase Chain Reaction
Protein C
Thrombosis

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