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Simple and rapid detection of factor V Leiden by allele-specific PCR amplification.

Thrombosis and haemostasis - 1 May 1996

Blasczyk R, Ritter M, Thiede C, Wehling J, Hintz G, Neubauer A, Riess H

Abstract excerpt

Resistance to activated protein C is the most common hereditary cause for thrombosis and significantly linked to factor V Leiden. In this study, primers were designed to identify the factor V mutation by allele-specific PCR amplification. 126 patients with thromboembolic events were analysed using this technique, PCR-RFLP and direct sequencing. The concordance between these techniques was 100%. In 27 patients a...

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PMID: 8725719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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