Article
Semi-automated detection of the factor V mutation by allele specific amplification and capillary electrophoresis.
Thrombosis and haemostasis - 1 Nov 1995
van de Locht L T, Kuypers A W, Verbruggen B W, Linssen P C, Nováková I R, Mensink E J
Abstract excerpt
Recently a point mutation (G1691A) in the coagulation factor V gene was shown to cause resistance for cleavage by activated protein C. The mutation is associated with an increased thrombotic risk and thus-far the most common genetic cause of thrombophilia. Current techniques to investigate the si...
Topics
- Alleles
- Base Sequence
- Electrophoresis, Capillary
- Factor V
- Humans
- Molecular Sequence Data
- Point Mutation
- Polymerase Chain Reaction
- Thrombosis