Article
Semi-automated detection of the factor V mutation by allele specific amplification and capillary electrophoresis.
Thrombosis and haemostasis - 1 Nov 1995
van de Locht L T, Kuypers A W, Verbruggen B W, Linssen P C, Nováková I R, Mensink E J
Abstract excerpt
Recently a point mutation (G1691A) in the coagulation factor V gene was shown to cause resistance for cleavage by activated protein C. The mutation is associated with an increased thrombotic risk and thus-far the most common genetic cause of thrombophilia. Current techniques to investigate the single base pair mutation at the DNA level use an assay based upon the polymerase chain reaction followed by restriction...
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