Article
Multiplex primer extension reaction and capillary electrophoresis to study the frequency of thrombophilia-related mutations in a spanish population.
Clinica chimica acta; international journal of clinical chemistry - 16 Aug 2012
Zafra-Ceres Mercedes, de Haro Tomás, Gómez-Capilla José Antonio, Farez-Vidal Esther, Poyatos Antonio, Gómez-Llorente Carolina
Abstract excerpt
BACKGROUND: Thrombophilia is defined as an inherited or acquired abnormality of hemostasis predisposing to thrombosis. While the most common thrombophilia has a genetic origin and is manifested by elevated circulating antiphospholipid antibodies, about 40% of cases presenting with thrombosis are acquired. Factor V Leiden G1691A, prothrombin G20210A, MTHFR C677T, and Factor XII C46T mutations are associated with...
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