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Article

Variant sequences of the Hexokinase II gene in familial NIDDM.

Diabetologia - 1 Mar 1996

Taylor R W, Printz R L, Armstrong M, Granner D K, Alberti K G, Turnbull D M, Walker M

Abstract excerpt

UNLABELLED: Hexokinase II (HKII) plays a central role in the intracellular metabolism of glucose in skeletal muscle, catalysing the phosphorylation of glucose to glucose 6-phosphate. It is therefore considered to be a potentially important candidate gene in the development of insulin resistance and non-insulin-dependent diabetes mellitus (NIDDM). The aim of this study was to screen the HKII gene for mutations in...

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PMID: 8721778
DOI: 10.1007/BF00418348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Variant sequences of the Hexokinase II gene in familial NIDDM.PMID 8721778Read ↗

Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity.Semantic proximity Read ↗

Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142-->His substitution.Semantic proximity Read ↗

Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity.Semantic proximity Read ↗

Amino acid substitutions in hexokinase II among patients with NIDDM.Semantic proximity Read ↗

The human hexokinase II gene promoter: functional characterization and detection of variants among patients with NIDDM.Semantic proximity Read ↗

Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance.Semantic proximity Read ↗

Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians.Semantic proximity Read ↗

Structure of the human hexokinase II gene.Semantic proximity Read ↗

Sequence variations of the glucokinase gene in Japanese subjects with NIDDM.Semantic proximity Read ↗

Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro.Semantic proximity Read ↗

A missense mutation, Val62Ala, in the glucokinase gene in a Norwegian family with maturity-onset diabetes of the young.Semantic proximity Read ↗

Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance.Semantic proximity Read ↗

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