Article
Sequence variations of the glucokinase gene in Japanese subjects with NIDDM.
Diabetes - 1 Aug 1993
Eto K, Sakura H, Shimokawa K, Kadowaki H, Hagura R, Akanuma Y, Yazaki Y, Kadowaki T
Abstract excerpt
Mutations in the glucokinase gene have been identified recently in patients with maturity-onset diabetes of the young, a subtype of NIDDM. The proposed role of glucokinase as a glucose sensor, combined with the low insulin response to glucose found in most Japanese with NIDDM, prompted us to spec...
Topics
- Adolescent
- Adult
- Base Sequence
- DNA Mutational Analysis
- Diabetes Mellitus, Type 2
- Exons
- Glucokinase
- Humans
- Japan
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Prevalence