Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance.

doi:10.1007/BF00400733

Back to search

Article

Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance.

Diabetologia - 1 May 1995

Laakso M, Malkki M, Kekäläinen P, Kuusisto J, Deeb S S

Abstract excerpt

Skeletal muscle and adipose tissue hexokinase II is a promising candidate gene for non-insulin-dependent diabetes mellitus (NIDDM) and insulin resistance. Therefore, we investigated the association of alleles at four polymorphic loci in this gene with NIDDM and insulin resistance in 110 Finnish d...

Topics

Adipose Tissue
Alleles
Base Sequence
Blood Glucose
DNA Primers
Diabetes Mellitus, Type 2
Exons
Female
Finland
Glucose Clamp Technique
Hexokinase
Homozygote
Humans
Insulin Resistance
Isoenzymes
Male
Middle Aged
Molecular Sequence Data

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.