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Article

The human hexokinase II gene promoter: functional characterization and detection of variants among patients with NIDDM.

Diabetologia - 1 Dec 1997

Malkki M, Laakso M, Deeb S S

Abstract excerpt

Hexokinase II (HKII) plays an important role in facilitating glucose uptake by skeletal muscle, heart, and adipose tissue in response to insulin. We have cloned and sequenced the proximal promoter region of the human HKII gene, determined the transcription start sites and screened the 2.0 kb of t...

Topics

Adipocytes
Animals
Base Sequence
Cell Line
Diabetes Mellitus, Type 2
Genetic Variation
Hexokinase
Humans
Insulin Resistance
Mice
Molecular Sequence Data
Muscle, Skeletal
Polymorphism, Single-Stranded Conformational

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Rats

Regulatory Sequences, Nucleic Acid

Repetitive Sequences, Nucleic Acid

Transcription, Genetic

Source

Identifiers

PMID: 9447955
DOI: 10.1007/s001250050850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9447955-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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