Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro.

doi:10.1007/BF02658512

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Article

Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro.

Diabetologia - 1 Oct 1996

Sakura H, Wat N, Horton V, Millns H, Turner R C, Ashcroft F M

Abstract excerpt

The ATP-sensitive K-channel plays a central role in insulin release from pancreatic beta cells. This channel consists of two subunits: a sulphonyl-urea receptor, SUR1, and an inwardly rectifying K-channel subunit, Kir6.2. We screened 135 white Caucasian patients with non-insulin-dependent diabete...

Topics

Amino Acid Sequence
Base Sequence
Black People
Caribbean Region
DNA Primers
DNA Transposable Elements
Diabetes Mellitus, Type 2
Exons
Genetic Variation
Genotype
Humans
Islets of Langerhans
Macromolecular Substances
Models, Structural

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Point Mutation

Polymerase Chain Reaction

Polymorphism, Single-Stranded Conformational

Source

Open in PubMed

Identifiers

PMID: 8897013
DOI: 10.1007/BF02658512

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8897013-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.