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Article

Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians.

Diabetes - 1 Jun 1996

Inoue H, Ferrer J, Welling C M, Elbein S C, Hoffman M, Mayorga R, Warren-Perry M, Zhang Y, Millns H, Turner R, Province M, Bryan J, Permutt M A, Aguilar-Bryan L

Abstract excerpt

NIDDM is a common heterogeneous disorder, the genetic basis of which has yet to be determined. The sulfonylurea receptor (SUR) gene, now known to encode an integral component of the pancreatic beta-cell ATP-sensitive potassium channel, IKATP, was investigated as a logical candidate for this disorder. The two nucleotide-binding fold (NBF) regions of SUR are known to be critical for normal glucose regulation of...

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PMID: 8635661
DOI: 10.2337/diab.45.6.825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians.PMID 8635661Read ↗

Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM.Semantic proximity Read ↗

Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro.Semantic proximity Read ↗

Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.Semantic proximity Read ↗

Sequence variants in the pancreatic islet beta-cell inwardly rectifying K+ channel Kir6.2 (Bir) gene: identification and lack of role in Caucasian patients with NIDDM.Semantic proximity Read ↗

Sulfonylurea receptor -1 (SUR1): genetic and metabolic evidences for a role in the susceptibility to type 2 diabetes mellitus.Semantic proximity Read ↗

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.Semantic proximity Read ↗

Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1Semantic proximity Read ↗

KCNJ11, ABCC8 and TCF7L2 polymorphisms and the response to sulfonylurea treatment in patients with type 2 diabetes: a bioinformatics assessment.Semantic proximity Read ↗

Metabolic control in type 2 diabetes is associated with sulfonylurea receptor-1 (SUR-1) but not with KCNJ11 polymorphisms.Semantic proximity Read ↗

Amino acid substitutions in hexokinase II among patients with NIDDM.Semantic proximity Read ↗

Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53).Semantic proximity Read ↗

Genetic analysis of Japanese patients with persistent hyperinsulinemic hypoglycemia of infancy: nucleotide-binding fold-2 mutation impairs cooperative binding of adenine nucleotides to sulfonylurea receptor 1.Semantic proximity Read ↗

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