Article
Amino acid substitutions in hexokinase II among patients with NIDDM.
Diabetes - 1 Mar 1995
Laakso M, Malkki M, Deeb S S
Abstract excerpt
Hexokinase (HK) II plays an important role in intracellular glucose metabolism by catalyzing the conversion of glucose to glucose-6-phosphate. HKII is considered to be a promising candidate gene for non-insulin-dependent diabetes mellitus (NIDDM) and insulin resistance. Therefore, we investigated the frequency of variants in the coding region of the HKII gene in patients with NIDDM. Initial screening included a...
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