Amino acid substitutions in hexokinase II among patients with NIDDM.

doi:10.2337/diab.44.3.330

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Article

Amino acid substitutions in hexokinase II among patients with NIDDM.

Diabetes - 1 Mar 1995

Laakso M, Malkki M, Deeb S S

Abstract excerpt

Hexokinase (HK) II plays an important role in intracellular glucose metabolism by catalyzing the conversion of glucose to glucose-6-phosphate. HKII is considered to be a promising candidate gene for non-insulin-dependent diabetes mellitus (NIDDM) and insulin resistance. Therefore, we investigated the frequency of variants in the coding region of the HKII gene in patients with NIDDM. Initial screening included a...

Topics

Amino Acid Sequence
Base Sequence
Blood Glucose
Codon
DNA Primers
Diabetes Mellitus, Type 2
Female
Finland
Genetic Variation
Glucose Tolerance Test
Hexokinase
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isoenzymes

Male

Middle Aged

Molecular Sequence Data

Point Mutation

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 7883120
DOI: 10.2337/diab.44.3.330

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7883120-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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