Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure of the human hexokinase II gene.

Biochemical and biophysical research communications - 30 Nov 1994

Malkki M, Laakso M, Deeb S S

Abstract excerpt

Mutations in the gene encoding hexokinase II which catalyzes a key step in glycolysis could contribute to the development of peripheral insulin resistance and lead to non-insulin-dependent diabetes mellitus. As a first step towards screening patients for mutations in this gene, we have determined its structure and the sequence of exon-intron junctions. The human HKII gene is composed of 18 exons that span at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exons
Share to Introns
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Base Sequence

Share to Diabetes Mellitus, Type 2

Share to Molecular Sequence Data

Share to Mutation

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 7999069
DOI: 10.1006/bbrc.1994.2692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure of the human hexokinase II gene.PMID 7999069Read ↗

Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity.Semantic proximity Read ↗

Hexokinase: gene structure and mutations.Semantic proximity Read ↗

Molecular characterization of six new cases of red blood cell hexokinase deficiency yields four novel mutations in HK1.Semantic proximity Read ↗

Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142-->His substitution.Semantic proximity Read ↗

Hexokinases in cancer and other pathologiesSemantic proximity Read ↗

Human hexokinase II: localization of the polymorphic gene to chromosome 2.Semantic proximity Read ↗

Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localizationSemantic proximity Read ↗

Dysregulated Pseudogene HK2P1 May Contribute to Preeclampsia as a Competing Endogenous RNA for Hexokinase 2 by Impairing DecidualizationSemantic proximity Read ↗

The human hexokinase II gene promoter: functional characterization and detection of variants among patients with NIDDM.Semantic proximity Read ↗

Structure of the human glucokinase gene and identification of a missense mutation in a Japanese patient with early-onset non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Molecular evolution of the vertebrate hexokinase gene family: Identification of a conserved fifth vertebrate hexokinase geneSemantic proximity Read ↗

Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.