Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142-->His substitution.

doi:10.2337/diab.44.3.340

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142-->His substitution.

Diabetes - 1 Mar 1995

Vidal-Puig A, Printz R L, Stratton I M, Granner D K, Moller D E

Abstract excerpt

Hexokinase II (HKII) is the predominant hexokinase isozyme expressed in insulin-responsive tissues. Since defects involving glucose transport and/or its phosphorylation to glucose-6-phosphate are present in muscle of insulin-resistant humans, HKII should be viewed as a candidate gene for inherited insulin resistance and susceptibility to non-insulin-dependent diabetes mellitus (NIDDM). To investigate the...

Topics

Adult
Amino Acid Sequence
Base Sequence
Blood Glucose
DNA Primers
Diabetes Mellitus
Diabetes Mellitus, Type 2
Exons
Female
Genetic Variation
Glutamine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glycated Hemoglobin

Hexokinase

Histidine

Humans

Hyperinsulinism

Insulin

Insulin Resistance

Source

Open in PubMed

Identifiers

PMID: 7883122
DOI: 10.2337/diab.44.3.340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7883122-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142-->His substitution.PMID 7883122Read ↗

Variant sequences of the Hexokinase II gene in familial NIDDM.Semantic proximity Read ↗

Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity.Semantic proximity Read ↗

Amino acid substitutions in hexokinase II among patients with NIDDM.Semantic proximity Read ↗

Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity.Semantic proximity Read ↗

The human hexokinase II gene promoter: functional characterization and detection of variants among patients with NIDDM.Semantic proximity Read ↗

Structure of the human hexokinase II gene.Semantic proximity Read ↗

Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus.Semantic proximity Read ↗

Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance.Semantic proximity Read ↗

Glucokinase gene variants in the common form of NIDDM.Semantic proximity Read ↗

Human hexokinase II: localization of the polymorphic gene to chromosome 2.Semantic proximity Read ↗

Molecular characterization of six new cases of red blood cell hexokinase deficiency yields four novel mutations in HK1.Semantic proximity Read ↗

Novel pathogenic variant c.2714C>A (p. Thr905Lys) in the HK1 gene causing severe haemolytic anaemia with developmental delay in an Indian family.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.