The apolipoprotein E epsilon 4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer's disease and Lewy body variant.

doi:10.1212/wnl.47.1.190

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Article

The apolipoprotein E epsilon 4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer's disease and Lewy body variant.

Neurology - 1 Jul 1996

Olichney J M, Hansen L A, Galasko D, Saitoh T, Hofstetter C R, Katzman R, Thal L J

Abstract excerpt

OBJECTIVE: To determine the relationship between apolipoprotein E (apoE) genotype and neuropathologic lesions in Alzheimer's disease (AD) and Lewy body variant (LBV). DESIGN: Retrospective genetic-neuropathologic study of AD and LBV cases. The main neuropathologic outcome measures were modeled as...

Topics

Aged
Aged, 80 and over
Alzheimer Disease
Analysis of Variance
Apolipoproteins E
Cerebral Amyloid Angiopathy
Female
Genotype
Humans
Lewy Bodies
Male

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