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Article

Association of the apolipoprotein E epsilon 4 allele with clinical subtypes of autopsy-confirmed Alzheimer's disease.

American journal of medical genetics - 15 Sept 1994

Zubenko G S, Stiffler S, Stabler S, Kopp U, Hughes H B, Cohen B M, Moossy J

Abstract excerpt

Consistent with previous reports, we observed a significant association of the APOE epsilon 4 allele with Alzheimer's Disease (AD) in a series of 91 autopsy-confirmed cases. The epsilon 4 allele frequency was higher in cases with a family history of AD-like dementia (0.54 +/- 0.07), although the epsilon 4 allele frequency in the AD cases with a negative family history (0.38 +/- 0.05) remained significantly...

Topics

Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoproteins E
Autopsy
Base Sequence
DNA
Female
Genotype
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Molecular Sequence Data

Polymerase Chain Reaction

Source

Identifiers

PMID: 7810577
DOI: 10.1002/ajmg.1320540306

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7810577-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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