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Article

TP53 mutational landscape of metastatic head and neck cancer reveals patterns of mutation selection

30 Jul 2020

Abstract excerpt

BACKGROUND: Head and neck squamous cell carcinoma is a heterogeneous disease with respect to the anatomic site of the primary tumor. On the other hand, it is highly recurrent, and once metastatic, it is associated with poor prognosis. TP53 is the most commonly mutated gene in primary disease. TP53 mutations occur in different structural elements of the protein while the biological outcome can be diverse. METHODS:...

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PMID: 32739866
DOI: 10.1016/j.ebiom.2020.102905

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