Article
[Analysis of mutations within the TP53 gene in patients with squamous cell carcinoma of the head and neck].
Otolaryngologia polska = The Polish otolaryngology - 1 Jan 2000
Golusinski Paweł, Lamperska Katarzyna, Pazdrowski Jakub, Golusinski Wojciech
Abstract excerpt
Head and neck cancer is the sixth most common type of cancer. Tobacco and alcohol consumption are implicated in 75% of all SCCHN and have a multiplicative combined effect. It is considered to be the main risk factor for the cancer development. The identification of a number of these genetic alterations, for example mutations in the p53 tumour suppressor gene, paved the way for their use as molecular markers....
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