Article
[Significance of aberrant p53 protein in head-neck tumors and its effect on proliferation and differentiation].
HNO - 1 May 1993
Homann N, Andl T, Nees M, Schuhmann A, Herold-Mende C, Bosch F X
Abstract excerpt
Mutation of the tumor suppressor gene p53 is the most frequent genetic alteration of human tumors. Our systematic immunohistochemical analysis of the p53 phenotype and the comparison to proliferation and differentiation has revealed that over 50% of the squamous cell carcinomas of the head and ne...
Topics
- Adenocarcinoma
- Adenoma
- Carcinoma, Adenoid Cystic
- Carcinoma, Basal Cell
- Carcinoma, Squamous Cell
- Cell Division
- Cell Transformation, Neoplastic
- Chromosome Aberrations
- DNA Probes
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Genes, p53
- Head and Neck Neoplasms
- Humans
- In Situ Hybridization
- Lymph Nodes
- Mucous Membrane
- Mutation