High-throughput quantitative analysis with cell growth kinetic curves for low copy number mutant cells.

doi:10.1007/s00216-012-6328-5

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Article

High-throughput quantitative analysis with cell growth kinetic curves for low copy number mutant cells.

Analytical and bioanalytical chemistry - 1 Oct 2012

Xing James Z, Gabos Stephan, Huang Biao, Pan Tianhong, Huang Min, Chen Jie

Abstract excerpt

The mutation rate in cells induced by environmental genotoxic hazards is very low and difficult to detect using traditional cell counting assays. The established genetic toxicity tests currently recognized by regulatory authorities, such as conventional Ames and hypoxanthine guanine phosphoribosyl-transferase (HPRT) assays, are not well suited for higher-throughput screening as they require large amounts of test...

Topics

Animals
Biosensing Techniques
Cell Proliferation
Cells
Cricetinae
High-Throughput Screening Assays
Hypoxanthine Phosphoribosyltransferase
Kinetics
Mutation

Source

Open in PubMed

Identifiers

PMID: 22941066
DOI: 10.1007/s00216-012-6328-5

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