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Article

Quantitation of the allelic imbalance provides evidence on tumour heterogeneity: a hypothesis.

Mutation research - 5 Jul 1996

Kiaris H, Spandidos D A

Abstract excerpt

The observation of loss of heterozygosity (LOH) in tumours represents a useful clue to the presence of tumour suppressor genes (TSGs). However, analysis of this phenomenon is often complicated by tumour heterogeneity and the presence of DNA from adjacent normal tissues. The present study suggests a quantitative approach for measurement of LOH which may help to distinguish between these possibilities and to...

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Identifiers

PMID: 8692204
DOI: 10.1016/0027-5107(96)00008-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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