Article
Heterogeneity of allelic deletions within melanoma metastases.
Melanoma research - 1 Aug 2001
Bogdan I, Xin H, Burg G, Böni R
Abstract excerpt
During the initiation and progression of malignant melanoma, a series of different genetic events accumulate on several different chromosomes. The biological heterogeneity of tumour cells presents a major problem, preventing effective treatment of melanoma. To examine the degree of genetic heterogeneity, we searched for allelic losses (loss of heterozygosity; LOH) on chromosomes 9p, 9q, 1p and 17p, examining...
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