Article
Evidence for linkage to and association with type 1 diabetes at the 3q21 region in the Finnish population.
Genes and immunity - 1 Jan 2006
Laine A-P, Turpeinen H, Veijola R, Hermann R, Simell O, Knip M, Ilonen J
Abstract excerpt
IDDM9-region on chromosome 3q has shown suggestive evidence for linkage to type 1 diabetes in some but not all genome scans. We analyzed 22 microsatellite markers in 121 Finnish type 1 diabetes multiplex families across the IDDM9-region. Two-point maximum LOD scores of 3.4 and 2.5 were detected with markers D3S1589 and D3S3606, respectively. Two markers were further tested for association using the transmission...
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