Article
A linkage study of 12 IDDM susceptibility loci in the Finnish population.
Diabetes/metabolism research and reviews - 1 Jan 2000
Laine Antti-Pekka, Nejentsev Sergei, Veijola Riitta, Korpinen Eija, Sjöroos Minna, Simell Olli, Knip Mikael, Akerblom Hans K, Ilonen Jorma
Abstract excerpt
BACKGROUND: HLA region is the major locus (IDDM1) of type 1 diabetes (T1D) susceptibility. It explains approximately 50% of the genetic background of T1D, indicating additional genetic determinants. Genome scans and candidate gene studies have generated several chromosomal candidate regions that may have a role in T1D development. METHODS: We tested 12 of these loci for linkage in 107 Finnish T1D multiplex...
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