Article
A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population. Childhood Diabetes in Finland (DiMe) Study Group.
Diabetologia - 1 Sept 1994
Fennessy M, Metcalfe K, Hitman G A, Niven M, Biro P A, Tuomilehto J, Tuomilehto-Wolf E
Abstract excerpt
In Finland the haplotype A2, Cw1, B56, DR4, DQ8 is the third most common haplotype in insulin-dependent diabetic (IDDM) patients and has the highest haplotype-specific absolute risk for IDDM. Cw1, B56, DR4, DQ8 haplotypes containing HLA-A alleles other than A2 are infrequent in the population and...
Topics
- Adolescent
- Alleles
- Base Sequence
- Child
- DNA Primers
- Diabetes Mellitus, Type 1
- Finland
- Genes, MHC Class I
- Genetic Predisposition to Disease
- HLA-A Antigens
- HLA-B Antigens
- HLA-C Antigens
- HLA-DR Antigens
- Humans
- Molecular Sequence Data
- Polymerase Chain Reaction
- Risk Factors