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Article

Diabetes susceptibility at IDDM2 cannot be positively mapped to the VNTR locus of the insulin gene.

Diabetologia - 1 May 1996

Doria A, Lee J, Warram J H, Krolewski A S

Abstract excerpt

An inconsistency has come to light between the conclusion of Lucassen et al. that IDDM2 (11p15.5) must lie within a 4.1 kilobase (kb) segment at the insulin (INS) locus and their own data showing statistically significant associations between insulin-dependent diabetes mellitus (IDDM) and markers beyond the boundaries of that segment. We present data from an independent study of 201 IDDM patients and 107...

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Identifiers

PMID: 8739920
DOI: 10.1007/BF00403307

Genes

INS

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Related research

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Research trail→

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Diabetes susceptibility at IDDM2 cannot be positively mapped to the VNTR locus of the insulin gene.PMID 8739920Read ↗

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Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibilitySemantic proximity Read ↗

The <i>TH01</i> microsatellite and <i>INS</i> VNTR are strongly associated with type 2 diabetes and fasting insulin secretionSemantic proximity Read ↗

IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.Semantic proximity Read ↗

Human type 1 diabetes and the insulin gene: principles of mapping polygenes.Semantic proximity Read ↗

Risk loci for type 2 diabetes - quo vadis?Semantic proximity Read ↗

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Variants in the human insulin gene that affect pre-mRNA splicing: is -23HphI a functional single nucleotide polymorphism at IDDM2?Semantic proximity Read ↗

Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group.Semantic proximity Read ↗

The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcriptionSemantic proximity Read ↗

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